Cochlear Fluids Research Laboratory
Alec N. Salt, Ph.D.
Department of Otolaryngology
Washington University School of Medicine
St. Louis, Missouri, 63110, USA
Fluid Spaces of the Inner Ear
The image shows an anatomically accurate 3-D reconstruction of the fluid spaces of the mammalian inner ear.
The upper, spiral structure is the cochlea, the part of the ear that is responsible for hearing. The lower parts include the vestibule and the semi-circular canals, that are responsible for balance.
We build 3-D representations of the ear into computer models that allow us to mathematically model how applied substances, such as drugs, disperse within the fluid and tissue spaces of the ear.
The structures are color-coded as follows: Orange: perilymph; Blue: endolymph; Pale Green: Spiral Ligament; Dark Green: Nerve;
Red: Cochlear aqueduct; Brown: Stapes; Blue-Gray: Round Window Membrane
A Pictorial Guide
to the Inner Ear
"Fluid in Your
Ears"
Anatomy of the Inner Ear
Cochlear Anatomy
Cochlear Fluids
Composition
The Endocochlear Potential
Endolymphatic Hydrops
Endolymph Flow in the
Normal Cochlea
Publications
from our Group
Cochlear Fluids
Studies
Perilymph Sampling from the Cochlear Apex
Computer
Simulations of Drug Movements in Cochlear Fluids
Introduction to the 1D
Fluids Simulator Program
Downloading,
Installation and Operating Instructions
Download Latest
Simulator Program V 1.6i, December 2005(1.7 Mb windows installation file)
Download and installation of this program should be performed with Microsoft Internet Explorer.
Documentation of
Simulator Revisions
Guidance for
setting Simulation Parameters
Cochlear Distortion
Simulator
Introduction to the Distortion
Simulation Program
Downloading,
Installation and Operating Instructions
Download the
Distortion Simulation Program V 1.1, October, 2003 (2.9 Mb Windows installation
file)
Download and installation of this program should be performed with Microsoft Internet Explorer.
Cochlear Fluid
Parameters Database
Dimensions of
Inner Ear Fluid Spaces
Composition of
Inner Ear Fluids
Resting Potentials of
Inner Ear Fluid Spaces
Longitudinal Flow
Rate of Cochlear Fluids
Diffusion
Coefficients for Various Solutes
Clearance
Characteristics for Various Solutes
Placement locations
of electrodes
3-D Imaging of the
Ear with OPFOS
3D Reconstruction of the Helicotrema
Fly through the cochlea
3-D Imaging of the
Ear with High-Resolution MR
Introduction and Personnel
Involved
High-resolution Magnetic Resonance
Microscopy (MRM) Technique
Cochlear Fluid Volumes
for the Guinea Pig
Cochlear Fluid Volumes
for the Human
Cochlear Fluid Volumes
for the Gerbil
Cochlear Fluid Volumes
for the Bat
Cochlear Fluid Volumes
for the Rat
Cochlear Fluid Volumes
for the Mouse
Relationship of the Round
Window to Scala Tympani
MR Imaging of the
Endolymphatic Sac
Department of Otolaryngology
The
Meniere's Page
Radio Controlled
Model Airplanes
Radio
Controlled Jets as a Hobby
St. Louis
Radio Control Flying Association
Alec Salt received the 1999 Guyot prize for research
Quotes that I like
"A
new scientific truth does not triumph by convincing its opponents and making them
see the light, but rather because its opponents eventually die and a new
generation grows up that are familiar with it."
Max Planck
"Fear
not the path of truth for the lack of people walking on it."
Robert F Kennedy
Comments are welcome at salta@msnotes.wustl.edu.
Web page established March 6,
1995
Pages last updated December 2008